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- 产品名称：Btk Phospho (pY551)
- 产品型号：EP267Y
- 产品展商：其它品牌
- 产品文档：无相关文档
- 发布时间：2018-07-07
- 在线询价
简单介绍
Btk (Bruton tyrosine kinase also known as BPK o r ATK) is a member of the TEC family of non-recept
o r protein tyrosine kinase which includes Bmx
产品描述
| 【产品类型】Rabbit Monoclonal IgG |
| 【产品批号】Q06187 |
【价格】2850元 |
| 【反应特异性】Human |
【克隆 ID】EP267Y |
| 【用途】WB , ICC |
【产品性状】 |
| 【阳性对照】 |
【产品浓度】 |
| 【细胞定位】 |
【抗原分子量】74 kDa |
| 【Database links】 |
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| 【其它名称】Bruton tyrosine kinase, Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenit o r kinase, BPK |
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【产品介绍】Btk (Bruton tyrosine kinase also known as BPK o r ATK) is a member of the TEC family of non-recept o r protein tyrosine kinase which includes Bmx, Itk a n d TEC. Btk is composed of a pleckstrin domain, an SH3 a n d SH2 domain, a catalytic kinase domain a n d a TEC homology domain (1). BTK plays a crucial role in B cell activation a n d development (2). Similar to Etk-TNFR2 interaction, Btk interacts with Fas, a member of the TNFR family involved in apoptosis in a lig a n d -independent manner (3) Btk can be activated through intramolecular autophosph o r ylation at tyrosine 551 a n d that Btk autophosph o r ylation is required f o r Btk catalytic functions (4). Mutations in the Btk gene have been linked to severe developmental blocks in human B-cell ontogeny leading to X-linked agammaglobulinemia (XLA). Patients with this disease are unusually prone to bacterial infection but not to viral infection (5).
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WB: 1:2,000
ICC: 1:100-250
Protocols f o r using Epitomics Rabbit Monoclonal Antibodies
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| A. Western blot analysis of anti-Btk phospho (pY551) RabMAb (cat. #1685-1), 1:2,000 dilution A: K562 cell lysate non-treated B: K562 cell lysate + Pervanadate C: Jurkat cell lysate non-treated D: Jurkat cell lysate + Pervanadate |
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参考文献:
1. Tsukada, S., Saffaran, D., Rawlings, D. & Witte, O. (1993) Cell 72, 279-290
2. Rawlings, D. J. & Witte, O. N. (1995) Semin. Immunol. 7, 237-246
3. Vassilev, A., Z. Ozer, C. Navara, S. Mahajan, a n d F. M. Uckun. 1999. J. Biol. Chem. 274:1646-1656
4. Mahajan S, Fargnoli J, Burkhardt A L, Kut S A, Saouaf S J, Bolen J B. Mol Cell Biol. 1995;15:5304–5311.
5. Yun Qiu, Dan Robinson, Tom G. Pretlow, a n d Hsing-Jien Kung, Cell Biology, Vol. 95, Issue 7, 3644-3649, March 31, 1998.
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