FTY720(Fingolimod HCL) C13690 上海佰世凯化学科技有限公司

FTY720(Fingolimod HCL)

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产品名称：FTY720(Fingolimod HCL)
产品型号：C13690
产品展商：Chembest
产品文档：无相关文档

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**抑制剂又称现货供应FTY720(Fingolimod HCL)/盐酸芬戈莫德对照品英文名：FTY720(Fingolimod HCL) 分子式：C19H33NO2.HCl 分子量： 343.9 纯度： >99% CAS No： 162359-56-0

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**抑制剂英文名：FTY720(Fingolimod HCL)

化学名称：2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride
分子式：C19H33NO2.HCl
分子量： 343.9
纯度： >99%
CAS No： 162359-56-0
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P₁, S1P₃, S1P₄, and S1P₅). Down-regulation of S1P₁ receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C₄ transporter Abcc1 and inhibits cytosolic phospholipase A₂ activity.

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FTY720(Fingolimod HCL)