尼达尼布 Nintedanib CAS:656247-17-5 C13378 上海佰世凯化学科技有限公司

尼达尼布 Nintedanib CAS:656247-17-5小分子抑制剂

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产品名称：尼达尼布 Nintedanib CAS:656247-17-5小分子抑制剂
产品型号：C13378
产品展商：Chembest
产品文档：无相关文档

简单介绍

BIBF-1120(Nintedanib,Vargatef)

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尼达尼布

Product Name:BIBF-1120(Nintedanib,Vargatef)

CAS No.:656247-17-5

Synonym:Nintedanib; BIBF 1120;Intedanib; Vargatef

Chemical name:(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate;methyl (3Z)-2-hydroxy-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-3H-indole-6-carboxylate

Molecular formula:C31H33N5O4

Molecular weight:539.62

Purity(HPLC):≥99%

Biological Activity:
BIBF 1120 is a triple receptor tyrosine kinase inhibitor, blocking signaling through VEGFR (IC50 = 13-34 nM), PDGFR (IC50 = 59-65 nM), and FGFR (IC50 = 37-610 nM). As all of these receptors are involved in angiogenesis, BIBF 1120 has utility in diseases that require new vessel formation. For example, BIBF 1120 has potential applications in various forms of cancer and pulmonary fibrosis.

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尼达尼布 Nintedanib CAS:656247-17-5小分子抑制剂