ICG-001(ICG 001); (S,S)-ICG 001;(6S,9aS)-六氢-6-[(4-羟基苯基)甲基]-8-(1-萘基甲基)-4,7-二氧代-N-(苯甲基)-2H-吡嗪并[1,2-a]嘧啶-1(6H)-甲酰胺;CAS:780757-88-2.
Formula:C33H32N4O4
Molecular Weight：548.63
Appearance：White or white crystalline powder
Purity：98+%
ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction.ICG-001 是 β-catenin/TCF 介导的转录抑制剂