Afatinib (BIBW2992)；阿法替尼；850140-72-6
Formula:C24H25ClFN5O3
Molecular Weight：485.94
Appearance：White solid powder
Purity：98+%
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.