CPI-0610；(4S)-6-(4-氯苯基)-1-甲基-4H-异恶唑并[5,4-D][2]苯并氮杂卓-4-乙酰胺；1380087-89-7
Formula:C20H16ClN3O2
Molecular Weight：365.81
Appearance：White to off-white powder
Purity：95%
Pelabresib (CPI-0610) is a potent and selective benzoisoxazoloazepine BET bromodomain inhibitor with an IC50 of 39 nM for BRD4-BD1 in TR-FRET assay and currently undergoing human clinical trials for hematological malignancies. CPI-0610 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.