产品名称：Monoclonal Antibody to Human C3a

产品介绍
品名	Monoclonal Antibody to Human C3a
货号	A203
规格	100 µL
同种型	IgG1k
蛋白质浓度	> 1.0 mg/mL
纯度	≥ 95% by SDS PAGE
缓冲液	Borate Buffered Saline (pH 8.4 ± 0.2)
储存	Storage: ≤ 30 Days 2-8˚C > 30 Days ≤ –20˚C
使用说明	For Research Use Only. Not for use in Diagnostic Procedures
产品描述	A murine monoclonal antibody to the human C3a domain of C3. This monoclonal antibody was raised against purified human C3. It is specific for an antigen expressed on the C3a domain of C3 and therefore reactive to C3 and C3a. Quidel's C3a monoclonal antibody has been used in a variety of experimental techniques including EIA and Western Blot. Please contact Quidel Technical Support for details on these or other applications. Because it is not specific for a neo-epitope on C3a, it may not be suitable for all EIA applications
背景	The human complement component, C3, consists of two disulfide-bonded subunits (Alpha – 115,000 kD and Beta – 75,000 kD). The concentration of C3 in serum is approximately 1.25 + 0.52 mg/ml. Under normal conditions, activation of either the Classical, Lectin or Alternative Complement Pathways produces C3 convertase which cleaves C3 into two fragments – C3a, an anaphylatoxin, and C3b.  Quidel’s monoclonal antibodies to complement antigens were prepared using standard techniques. They are purified from mouse ascites fluid via Protein A affinity chromatography. Quidel’s Anti-Human C3a monoclonal antibody was raised against highly pure human C3 protein.
应用
参考资料	Tamerius, J.D., Pangburn, M., et al. Detection of a neoAntigen on human iC3b and C3d by monoclonal Antibody, J. Immunol. 135:2015, 1985. Tamerius, J.D., Pangburn, M., et al. Selective inhibition of functional sites of cell bound C3b by hybridoma derived antibodies, J. Immunol 128:512, 1982.