全部产品分类
企业信息
12
  • 入驻时间: 2012-04-17
  • 联系人:客户经理
  • 电话:400-968-7988
  • 联系时,请说明易展网看到的
  • Email:fuwu@bioleaf.com
产品详情
  • 产品名称:Monoclonal Antibody to Human Factor P#1

  • 产品型号: A233
  • 产品厂商:Quidel
  • 产品价格:0
  • 折扣价格:0
  • 产品文档:
你添加了1件商品 查看购物车
简单介绍:
详情介绍:

产品介绍

品名

Monoclonal Antibody to Human Factor P#1 

货号

A233 

规格

100 µL

 同种型

IgG1k

蛋白质浓度

> 1.0 mg/mL

纯度

≥ 95% by SDS PAGE

缓冲液

Borate Buffered Saline (pH 8.4 ± 0.2)

物种交叉反应

None

储存

≤ 30 Days 2-8˚C 

> 30 Days ≤ –20˚C

使用说明

For Research Use Only. Not for use in Diagnostic Procedures

产品描述

A murine monoclonal antibody to an epitope on Factor P.

This monoclonal antibody was raised against purified Factor P. It inhibits the function of Factor P.

Quidel's Factor P Monoclonal Antibody #1 has been used in a variety of experimental techniques including EIA

背景

The function of Properdin (Factor P) is to stabilize the alternative pathway convertase. Its binding to C3bBb extends the half-life of the complex. The concentration in plasma is approximately 20 μg/mL. Factor P has a molecular weight of 224 kDa, consisting of four identical chains of approximately 53 kDa molecular weight. 

The alternative complement pathway provides innate protection against microbial agents in the absence of specific antibody. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells and cancer cells. In autoimmune diseases, the alternative complement pathway may contribute directly to tissue damage. 

特异性

The specificity of the monoclonal antibody was established via ELISA and RIA. This antibody was shown to bind to highly purified Factor P, but not to C3, Factor B, Factor H, nor other isolated complement proteins. The antibody was also shown to immunoprecipitated radiolabeled Factor P, using protein A-bearing bacteria to capture the immune complex. The antibody was shown to inhibit the binding of radiolabeled Factor P to EC3b cells. 

应用

 

参考资料

1、Shiraishi, M. et al. Improved hepatic microcirculation by human soluble urinary thrombomodulin in the xeno-perfused porcine liver. Transplantation 731:1046-1050 (2001). 

2、Harboe, M. et al. The role of properdin in zymosan- and Escherichia coli-induced complement activation. J Immunol 189(5):2606- 2613 (2012)


标题:
内容:
联系人:
联系电话:
Email:
公司名称:
联系地址:
 
 
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关文章

沪公网安备 31011202007338号