产品名称：Monoclonal Antibody to Human C4 (C4c)

产品介绍
品名	Monoclonal Antibody to Human C4 (C4c)
货号	A211
规格	100 µL
同种型	IgG1K
蛋白质浓度	> 1.0 mg/mL
缓冲液	Borate Buffered Saline (pH 8.4 ± 0.2)
物种交叉反应	Human, baboon.
储存	≤ 30 Days 2-8˚C  > 30 Days ≤ –20˚C
背景	Activation of the classical complement pathway begins with the binding of an activating substance (e.g. immune complex) to the C1q molecule of C1.This, in turn, activates the C1r(2)C1s(2) sub-units,resulting in cleavage of C4 to C4b near the amino terminus of the gamma chain releasing C4a in the process. The short-lived C4b molecule can bind covalently to membranes or other surfaces via either an amide or ester bond. This is an inefficient process that is limited to the immediate vicinity of the C1 complex. C4b then takes part in the classical convertase enzyme. Because of the short life of the C4b molecule much of the C4d is free and circulates in serum
描述	A murine monoclonal antibody to an epitope in the C4c domain of C4. This monoclonal antibody was raised against purified human C. It is specific for an antigen expressed on the C4c domain of C4 and therefore reactive to C4 and all C4c-containing  fragments of C4. Quidel's C4 (C4c) monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, Flow Cytometry, RIA, Hemagglutination and Immunohistochemistry.
应用	Because specific techniques differ from lab to lab, the provided information should be used as a guideline only.
参考文献	1、Pascher, A. et al. Immunopathological observations after xenogeneic liver perfusions using donor pigs transgenic for human decayaccelerating factor 1,2. Transplantation 64:384-391 (1997).  2、Barilla-LaBarca, M.L. et al. Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol 168:6298-6304 (2002).