产品名称：Monoclonal Antibody to Human Factor H#1

产品介绍
品名	Monoclonal Antibody to Human Factor H#1
货号	A229
规格	100 µL
同种型	IgG1k
蛋白质浓度	> 1.0-1.2 mg/mL
缓冲液	Borate Buffered Saline
物种交叉反应	Horse, Cynomolgus Monkey
储存	≤ 30 days 2°C to 8 °C  > 30 days ≤ –20 °C
使用说明	For Research Use Only. Not for use in diagnostic procedures
背景	Factor H is a fluid phase complement regulatory protein consisting of a single peptide chain of 20 short consensus repeat segments or CCP’s with a molecular weight of approximately 155 KD. Factor H regulates the alternative pathway of the complement system by modifying activity of the “feedback loop.” It does this in three ways. First, it is a co-factor for the serine protease Factor I, which cleaves C3b to iC3b. iC3b has no hemolytic or amplification function, but may be bound by complement receptors. Second, Factor H prevents the formation of and accelerates the disassociation of the alternative pathway C3 convertase, C3bBb from cell surfaces. Finally, Factor H binds to polyanions on host cell surfaces and tissue matrices, such as basement membranes, blocking deposition of C3b. This later activity is leveraged by many pathogens as a mode of complement evasion. 1
描述	All of Quidel’s monoclonal antibodies to complement antigens were prepared using intact complement proteins and are purified from mouse ascites fluid via protein A affinity chromatography. The prepared monoclonal antibodies are buffer exchanged in Borate Buffered Saline containing 0.02% NaN3.
应用	Applications of this antibody have been evaluated by various research facilities, and include EIA, 7 RIA, Western Blot, 4 IHC, 5 Flow Cytometry, 6 and Ligand Dot Blot. 6
参考资料	1、Kraiczy, P., Würrzner, R. Complement escape of human pathogenic bacteria by acquisition of complement regulators. Mol Immunol 43:21-44 (2006).  2、Sivaprasad, S. and Chong, N.V. The complement system and age related macular degeneration. Eye (2006), 1-6.  3、Atkinson, J.P., et al. Complement factor H and the hemolytic uremic syndrome. JEM Vol. 204, No. 6, June 11, 20071245–1248.  4、Fedarko, N.S., et al. Factor H binding to bonesialoprotein and osteopontin enables tumor cell evasion of complement mediated attack. JBC 27%:22 (2000).