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  • 入驻时间: 2012-04-17
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  • 产品名称:CD49d Antibody (PerCP)

  • 产品型号:abx200355
  • 产品厂商:Abbexa
  • 产品价格:400
  • 折扣价格:0
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简单介绍:
CD49d Antibody (PerCP)
详情介绍:
The CD29 antigen, also known as the ?-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the ? integrin, forms a lymphocyte homing receptor for Peyer's patch, binding tothe mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin.

Target CD49d
Reactivity Human
Host Mouse
Clonality Monoclonal
Tested Applications FCM
Recommended dilutions FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Tissue / cell preparation (JM leukemia line).
Purification Affinity Chromatography
Form Liquid
Isotype IgG1
Conjugation PerCP
Specificity CD49d (Anti–VLA-α-4) recognizes the 150-kilodalton (kd) α-chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of α and ? subunits and is involved in cell–cell and cell–extracellular matrix interactions. The ?-chain of the VLA-4 complex is the CD29 antigen, a 130-kd glycoprotein.
Storage Store in the dark at 2-8 °C.
Molecular Weight 150 kDa
Swiss Prot P13612
GeneID 3676
Buffer The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Availability Shipped within 2-3 weeks.
Note This product is for research use only.
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