企业信息
第12年
- 入驻时间: 2012-04-17
- 联系人:客户经理
- 电话:400-968-7988
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- Email:fuwu@bioleaf.com
产品详情
简单介绍:
ATRX Antibody
详情介绍:
ATRX Antibody detects endogenous levels of ATRX. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. Theses mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Target | ATRX |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Tested Applications | IF/ICC |
Recommended dilutions | IF/ICC: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
Immunogen | A synthesized peptide derived from human ATRX. |
Purification | Immunogen affinity purified. |
Conjugation | Unconjugated |
Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
Molecular Weight | 282 kDa |
Swiss Prot | P46100 |
Gene Symbol | ATRX |
Enzyme Commission Number | EC 3.6.1.- |
Buffer | Rabbit IgG in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Availability | Shipped within 5-10 working days. |
Note | This product is for research use only. |
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