Glycan remodeling of human IgG with the G0, G1, G2, G2S2 or Man5 glycoform, with core afucosylation.
TransGLYCIT Remodeling Afucosylated is a platform technology for efficient transglycosylation of native human IgG in a few hours. The robust workflow transglycosylates the antibody Fc N-glycans using enzymatic remodeling, resulting in a homogenous pool of antibodies carrying a defined glycoform (G0, G1, G2, G2S2 or Man5) with core afucosylation.
TransGLYCIT Remodeling Afucosylated is provided in kits containing sufficient material to transglycosylate 1 mg human IgG.
•Fast and efficient generation of human IgG with fully afucosylated homogeneous glycoforms
•Complete removal of core fucose to investigate its impact in functional assays
•Reliable glycan remodeling achieved within a few hours
