如果您对该产品感兴趣的话，可以
产品名称：Mouse/Rat FGF-23 (C-Term) ELISA
产品型号：60-6300
产品展商：Quidel
产品文档：无相关文档
发布时间：2016-12-30
在线询价

简单介绍

Fibroblast growth factor 23 (FGF-23) is a recently discovered, novel member of a large family of related proteins. Its gene encodes a 251 amino acid protein. The amino-terminal portion of FGF-23 (aa 1-24) is hydrophobic and is likely to serve as a signal peptide allowing its secretion into the blood circulation.

产品描述

Mouse/Rat FGF-23 (C-Term) ELISA

For Research Use Only. Not for use in diagnostic procedures

Renal phosphate wasting disorders leading to hypophosphatemia are among the causes of defective mineralization of bone and growth plate development. Autosomal dominant hypophosphatemic rickets (ADHR), a rare genetic disorder, results from one of several different FGF-23 mutations that make the protein resistant to proteolytic cleavage. Furthermore, tumors that cause oncogenic osteomalacia (OOM) have been shown to overexpress FGF-23 mRNA making it likely that elevated concentrations of FGF-23 in the blood are the cause of renal phosphate wasting. Consistent with this conclusion, the administration of recombinant FGF-23 to rodents was shown to increase urinary excretion of phosphate thus leading to hypophosphatemia and osteomalacia/rickets. Recent studies with chronic kidney disease (CKD) patients have shown FGF-23 to be an early predictor of abnormal renal tubular function, bone mineralization, disease severity and over-all mortality risk.

Taken together, all currently available data suggest that the measurement of<br>FGF-23 levels may provide an important diagnostic tool for the evaluation of hypophosphatemic and hyperphosphatemic disorders

This Mouse FGF-23 (C-Term) ELISA Kit is a homologous, two-site enzyme-linked immunosorbent ***** (ELISA) for the measurement of FGF-23 in plasma or cell culture media. Two affinity purified goat polyclonal antibodies have been selected to detect epitopes within the carboxyl-terminal (C-Term) region of mouse FGF-23. One antibody is biotinylated for capture and the other antibody is conjugated with the enzyme horseradish peroxidase (HRP) for detection.