Anti-CDCA7L/FITC抗体 Anti-CDCA7L/FITC
产品简介
Anti-CDCA7L/FITC抗体和抗原之间的结合具有高度的特异性,**组织化学正是利用了这一原理。先将组织或细胞中的某种化学物质提取出来,以此作为抗原或半抗原,Anti-CDCA7L/FITC抗体通过**动物后获得特异性的抗体,再以此抗体去探测组织或细胞中的同类的抗原物质。由于抗原与抗体的复合物是无色的,因此还必须借助于组织化学的方法将抗原抗体结合的部位显示出来,以其达到对组织或细胞中的未知抗原进行定性,定位或定量的研究。
产品详细信息
Anti-CDCA7L/FITC抗体
产品编号YB-5963R-FITC
英文名称Anti-CDCA7L/FITC
中文名称FITC标记的细胞分裂周期相关蛋白JPO2抗体
别 名c Myc Interacting protein JPO2; DKFZp762L0311; RAM2; HR1; JPO2; Protein JPO2; R1 antibody Transcription Factor RAM2.CDA7L_HUMAN
Anti-CDCA7L/FITC抗体
说 明 书100ul
研究领域细胞生物 **学 信号转导 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
Anti-CDCA7L/FITC抗体性 状Lyophilized or Liquid
浓 度1mg/ml
*** 原KLH conjugated synthetic peptide derived from human CDCA7L
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-CDCA7L/FITC抗体
产品介绍background:
CDCA7L is a member of the CDCA (cell division cycle associated) protein family. Members of this family have expression patterns associated with other known cell cycle genes such as cyclins and CDC genes. CDCA7L plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. It also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It is involved in apoptotic signaling pathways and may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Function:
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Subunit:
Interacts with MYC and PSIP1.
Subcellular Location:
Cytoplasm. Nucleus. Note=Associates with chromatin. Anti-CDCA7L/FITC抗体Translocates from cytoplasm to nucleus under dexamethasone induction.
Tissue Specificity:
Ubiquitous. Overexpressed in medulloblastoma.
Post-translational modifications:
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.