Anti-CDCA7L/FITC抗体 Anti-CDCA7L/FITC

Anti-CDCA7L/FITC抗体

产品编号YB-5963R-FITC

英文名称Anti-CDCA7L/FITC

中文名称FITC标记的细胞分裂周期相关蛋白JPO2抗体

别    名c Myc Interacting protein JPO2; DKFZp762L0311; RAM2; HR1; JPO2; Protein JPO2; R1 antibody Transcription Factor RAM2.CDA7L_HUMAN

Anti-CDCA7L/FITC抗体

说 明 书100ul  

研究领域细胞生物  **学  信号转导  细胞周期蛋白  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

产品应用IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量49kDa

Anti-CDCA7L/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

*** 原KLH conjugated synthetic peptide derived from human CDCA7L

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CDCA7L/FITC抗体

产品介绍background:

CDCA7L is a member of the CDCA (cell division cycle associated) protein family. Members of this family have expression patterns associated with other known cell cycle genes such as cyclins and CDC genes. CDCA7L plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. It also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It is involved in apoptotic signaling pathways and may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Function:

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Subunit:

Interacts with MYC and PSIP1.

Subcellular Location:

Cytoplasm. Nucleus. Note=Associates with chromatin. Anti-CDCA7L/FITC抗体Translocates from cytoplasm to nucleus under dexamethasone induction.

Tissue Specificity:

Ubiquitous. Overexpressed in medulloblastoma.

Post-translational modifications:

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.