胸苷磷酸化酶抗体 thymidine phosphorylase

胸苷磷酸化酶抗体

规格：1mg/1ml

英文名： thymidine phosphorylase

别名： ECGF 1; PDEGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Gliostatin; hPD ECGF; MNGIE; PD ECGF; PDECGF; PDEGF; Platelet derived endothelial growth fact

分子量： 50kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human Thymidin

交叉反应：Human,

细胞定位：

胸苷磷酸化酶抗体产品介绍：background: In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites. Function: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Subunit:胸苷磷酸化酶抗体 Homodimer. DISEASE: Defects in TYMP are the cause of mitochondrial DNA depletion syndrome type 1 (MTDPS1) [MIM:603041]; also known as myoneurogastrointestinal encephalomyopathy. A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy. Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Gene ID: 1890 Database links: Entrez Gene: 1890 Human Entrez Gene: 72962 Mouse Entrez Gene: 胸苷磷酸化酶抗体315219 Rat Omim: 131222 Human SwissProt: P19971 Human SwissProt: Q99N42 Mouse SwissProt: Q5FVR2 Rat Unigene: 180903 Human Unigene: 730607 Human Unigene: 287977 Mouse Unigene: 219088 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胸苷磷酸化酶（TP）是一种分子量为50-55kDa的蛋白，在氟嘧啶转化过程中起重要作用。TP具有血管生成活性，与血小板源性内皮细胞生长因子的结构和作用相似，因此又被称为肿瘤相关血管生长因子。其可能通过血管生成作用促进癌细胞的生长和转移。

胸苷磷酸化酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  **学  激酶和磷酸酶  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid