产品名称：Anti-CD144/VE Cadherin/FITC抗体

Anti-CD144/VE Cadherin/FITC抗体

产品编号YB-0878R-FITC

英文名称Anti-CD144/VE Cadherin/FITC

中文名称FITC标记的上皮型钙粘附分子抗体

别    名VE-cadherin; cadherin-5; VE-Cadherin;Cdh5; Vascular endothelial cadherin; 7B4 antigen; CD144 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; Vascular epithelium cadherin; VE Cad antibody VE-cadherin; VE cadherin; VEC; CADH5_HUMAN.  

Anti-CD144/VE Cadherin/FITC抗体

说 明 书100ul  

研究领域肿瘤  心血管  **学  信号转导  细胞粘附分子  血管内皮细胞  上皮细胞  内皮细胞  细胞外基质  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应 Mouse, Rat,

产品应用Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量86kDa

细胞定位细胞膜

Anti-CD144/VE Cadherin/FITC抗体性    状Lyophilized or Liquid

浓    度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from mouse Vascular endothelial cell cadherin

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CD144/VE Cadherin/FITC抗体

产品介绍background:

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].

Function:

Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Anti-CD144/VE Cadherin/FITC抗体Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Subunit:

Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1.

Subcellular Location:

Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.

Tissue Specificity:

Endothelial tissues and brain.

Post-translational modifications:

Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.

Similarity:

Contains 5 cadherin domains.

Database links:

Entrez Gene: 1003 Human

Entrez Gene: 12562 Mouse

Entrez Gene: 307618 Rat

Omim: 601120 Human

SwissProt: P33151 Human

SwissProt: P55284 Mouse

Unigene: 76206 Human

Unigene: 21767 Mouse

Unigene: 224644 Rat

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

血管内皮钙粘蛋白(Vascularendothelial cell cadherin;VE-cadherin;VECD),又名CD144,Cadherin-5,是AJ连接（粘附连接）的主要粘附分子,是维持血管内皮细胞极性和完整性必不可少的内皮细胞特异性钙粘蛋白.