[
PP 121
]
Product Name:
PP 121
Product Model:
C14043
Manufacturer:
P
file:
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Product Description
PP 121#1092788-83-4#C17H17N7#319.36#Soluble in DMSO and ethanol# #>99%#500mg,1g,2g,5g#Store at +4°C#Dual kinase inhibitor; inhibits PI 3K family kinases.
PP 121
Chemical Name: 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological Activity:
Dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.