Anti-5mC antibody [S4004RM] (STJ11104004) STJ11104004 上海玉博生物科技有限公司

Anti-5mC antibody [S4004RM] (STJ11104004)

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产品名称：Anti-5mC antibody [S4004RM] (STJ11104004)
产品型号：STJ11104004
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-5mC antibody [S4004RM] (STJ11104004)

产品描述

Host:	Rabbit
Reactivity:	Species independent
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-5mC is suitable for use in research applications.

Clonality:	Monoclonal
Clone ID:	S4004RM
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	DB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Immunogen:	5mC
Immunogen Sequence:	5mC conjugated to KL H

Background

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factor (s) to DNA. During development, the pattern of DNA methylation in the genome changes as a result of a dynamic process involving both de novo DNA methylation and demethylation. As a consequence, differentiated cells develop a stable and unique DNA methylation pattern that regulates tissue-specific gene transcription.? Intriguingly, postmitotic neurons still express DNA methyltransferases and components involved in DNA demethylation. Moreover, neuronal activity can modulate their pattern of DNA methylation in response to physiological and environmental stimuli. The precise regulation of DNA methylation is essential for normal cognitive function.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-5mC antibody [S4004RM] (STJ11104004)