Anti-A Cyclase V/VI antibody (931-980 aa) (STJ91398) STJ91398 上海玉博生物科技有限公司

Anti-A Cyclase V/VI antibody (931-980 aa) (STJ91398)

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产品名称：Anti-A Cyclase V/VI antibody (931-980 aa) (STJ91398)
产品型号：STJ91398
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-A Cyclase V/VI antibody (931-980 aa) (STJ91398)

产品描述

Host:	Rabbit
Applications:	IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Adenylate cyclase type 6 and Adenylate cyclase type 5 (931-980 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ADCY6 ADCY5
Gene ID:	112 111
Uniprot ID:	ADCY6_HUMAN ADCY5_HUMAN
Immunogen Region:	931-980 aa
Specificity:	A Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human ADCY5/6 at the amino acid range 931-980

Post Translational Modifications	Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA at Ser-662 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC at Ser-556, Ser-662 and Thr-919 inhibits catalytic activity.
Function	Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
Protein Name	Adenylate Cyclase Type 6 Atp Pyrophosphate-Lyase 6 Adenylate Cyclase Type Vi Adenylyl Cyclase 6 Ca(2+-Inhibitable Adenylyl Cyclase
Database Links	Reactome: R-HSA-163359 Reactome: R-HSA-163615 Reactome: R-HSA-164378 Reactome: R-HSA-170660 Reactome: R-HSA-170670 Reactome: R-HSA-381676 Reactome: R-HSA-400042 Reactome: R-HSA-418555 Reactome: R-HSA-418594 Reactome: R-HSA-418597 Reactome: R-HSA-432040 Reactome: R-HSA-5610787 Reactome: R-HSA-9660821 Reactome: R-HSA-9664323
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Projection Cilium Stereocilium
Alternative Antibody Names	Anti-Adenylate Cyclase Type 6 antibody Anti-Atp Pyrophosphate-Lyase 6 antibody Anti-Adenylate Cyclase Type Vi antibody Anti-Adenylyl Cyclase 6 antibody Anti-Ca(2+-Inhibitable Adenylyl Cyclase antibody Anti-ADCY6 antibody Anti-KIAA0422 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-A Cyclase V/VI antibody (931-980 aa) (STJ91398)