Active Human ErbB-2/HER2/CD340 protein (Recombinant) (C-His) (STJP002595) STJP002595 上海玉博生物科技有限公司

Active Human ErbB-2/HER2/CD340 protein (Recombinant) (C-His) (STJP002595)

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产品名称：Active Human ErbB-2/HER2/CD340 protein (Recombinant) (C-His) (STJP002595)
产品型号：STJP002595
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Active Human ErbB-2/HER2/CD340 protein (Recombinant) (C-His) (STJP002595)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Active Human ErbB-2/HER2/CD340-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized recombinant human ERBB2 at 10 ng/mL (100 Mu L/well) can bind Trastuzumab with a linear range of 4-20 ng/mL.

Gene Symbol:	ERBB2
Gene ID:	2064
Uniprot ID:	ERBB2_HUMAN
Immunogen Region:	Thr23-Thr652
Immunogen:	Active Recombinant Human ErbB-2/HER2/CD340 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr23-Thr652) of human HER2/ErbB2 (Accession #NP_004439.2) fused with a 6×His tag at the C-terminus.

Post Translational Modifications	Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues. Signaling via SEMA4C promotes phosphorylation at Tyr-1248. Dephosphorylated by PTPN12.
Function	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A.the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Protein Name	Receptor Tyrosine-Protein Kinase Erbb-2 Metastatic Lymph Node Gene 19 Protein Mln 19 Proto-Oncogene Neu Proto-Oncogene C-Erbb-2 Tyrosine Kinase-Type Cell Surface Receptor Her2 P185erbb2 Cd Antigen Cd340
Database Links	Reactome: R-HSA-1227986 Reactome: R-HSA-1250196 Reactome: R-HSA-1251932 Reactome: R-HSA-1257604 Reactome: R-HSA-1306955 Reactome: R-HSA-1358803 Reactome: R-HSA-1963640 Reactome: R-HSA-1963642 Reactome: R-HSA-2219530 Reactome: R-HSA-416572 Reactome: R-HSA-5673001 Reactome: R-HSA-6785631 Reactome: R-HSA-6811558 Reactome: R-HSA-8847993 Reactome: R-HSA-8863795 Reactome: R-HSA-8866910 Reactome: R-HSA-9634285 Reactome: R-HSA-9652282 Reactome: R-HSA-9664565 Reactome: R-HSA-9665233 Reactome: R-HSA-9665244 Reactome: R-HSA-9665245 Reactome: R-HSA-9665246 Reactome: R-HSA-9665247 Reactome: R-HSA-9665249 Reactome: R-HSA-9665250 Reactome: R-HSA-9665251 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9665737
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Projection Ruffle Membrane Internalized From The Cell Membrane In Response To Egf Stimulation Isoform 1: Cell Membrane Early Endosome Cytoplasm Perinuclear Region Nucleus Translocation To The Nucleus Requires Endocytosis Probably Endosomal Sorting And Is Mediated By Importin Beta-1/Kpnb1 Also Detected In Vps35-Positive Endosome-To-Tgn Retrograde Vesicles Isoform 2: Cytoplasm Isoform 3: Cytoplasm
Alternative Protein Names	Receptor Tyrosine-Protein Kinase Erbb-2 protein Metastatic Lymph Node Gene 19 Protein protein Mln 19 protein Proto-Oncogene Neu protein Proto-Oncogene C-Erbb-2 protein Tyrosine Kinase-Type Cell Surface Receptor Her2 protein P185erbb2 protein Cd Antigen Cd340 protein ERBB2 protein HER2 protein MLN19 protein NEU protein NGL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Active Human ErbB-2/HER2/CD340 protein (Recombinant) (C-His) (STJP002595)