Active Human TNFSF11/RANKL/CD254 protein (Recombinant) (N-His) (STJP002596) STJP002596 上海玉博生物科技有限公司

Active Human TNFSF11/RANKL/CD254 protein (Recombinant) (N-His) (STJP002596)

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产品名称：Active Human TNFSF11/RANKL/CD254 protein (Recombinant) (N-His) (STJP002596)
产品型号：STJP002596
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Active Human TNFSF11/RANKL/CD254 protein (Recombinant) (N-His) (STJP002596)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Active Human TNFSF11/RANKL/CD254-N-His protein was developed from hek293 cells and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	1.Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF11 Protein at 2 Mu g/mL (100 Mu L/well) can bind Mouse TNFRSF11B with a linear range of 0.049-13.74 ng/mL.2.Measured by its ability to induce osteoclast differentiation o

Gene Symbol:	TNFSF11
Gene ID:	8600
Uniprot ID:	TNF11_HUMAN
Immunogen Region:	Gly136-Asp317
Immunogen:	Active Recombinant Human TNFSF11/RANKL/CD254 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly136-Asp317) of human TRANCE/RANK L/TNFSF11 (Accession #NP_143026.1) fused with a 6×His tag at the N-

Post Translational Modifications	The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17.
Function	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.
Protein Name	Tumor Necrosis Factor Ligand Superfamily Member 11 Osteoclast Differentiation Factor Odf Osteoprotegerin Ligand Opgl Receptor Activator Of Nuclear Factor Kappa-B Ligand Rankl Tnf-Related Activation-Induced Cytokine Trance Cd Antigen Cd254 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 11 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 11 - Soluble Form
Database Links	Reactome: R-HSA-5668541 Reactome: R-HSA-5669034 Reactome: R-HSA-5676594
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type Ii Membrane Protein Isoform 3: Cell Membrane Isoform 2: Cytoplasm Tumor Necrosis Factor Ligand Superfamily Member 11 Soluble Form: Secreted
Alternative Protein Names	Tumor Necrosis Factor Ligand Superfamily Member 11 protein Osteoclast Differentiation Factor protein Odf protein Osteoprotegerin Ligand protein Opgl protein Receptor Activator Of Nuclear Factor Kappa-B Ligand protein Rankl protein Tnf-Related Activation-Induced Cytokine protein Trance protein Cd Antigen Cd254 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 11 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 11 - Soluble Form protein TNFSF11 protein OPGL protein RANKL protein TRANCE protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Active Human TNFSF11/RANKL/CD254 protein (Recombinant) (N-His) (STJP002596)