5HT2A Receptor Blocking Peptide peptide (STJ505508) STJ505508-250 上海玉博生物科技有限公司

5HT2A Receptor Blocking Peptide peptide (STJ505508)

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产品名称：5HT2A Receptor Blocking Peptide peptide (STJ505508)
产品型号：STJ505508-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

5HT2A Receptor Blocking Peptide peptide (STJ505508)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	5HT2A Receptor Blocking Peptide is synthetically produced from the 400-450 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	HTR2A
Gene ID:	3356
Uniprot ID:	5HT2A_HUMAN
Immunogen Region:	400-450
Immunogen:	Synthetic peptide taken within amino acid region 400-450 on human 5-hydroxytryptamine receptor 2A.

Tissue Specificity	Detected in brain cortex (at protein level). Detected in blood platelets.
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.
Peptide Name	5-Hydroxytryptamine Receptor 2a 5-Ht-2 5-Ht-2a Serotonin Receptor 2a
Database Links	Reactome: R-HSA-390666 Reactome: R-HSA-416476
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendrite Axon Cytoplasmic Vesicle Membrane Caveola Presynapse
Alternative Peptide Names	5-Hydroxytryptamine Receptor 2a protein 5-Ht-2 protein 5-Ht-2a protein Serotonin Receptor 2a protein HTR2A protein HTR2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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5HT2A Receptor Blocking Peptide peptide (STJ505508)