ABL2 Blocking Peptide for STJ506089 peptide (STJ505824) STJ505824-250 上海玉博生物科技有限公司

ABL2 Blocking Peptide for STJ506089 peptide (STJ505824)

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产品名称：ABL2 Blocking Peptide for STJ506089 peptide (STJ505824)
产品型号：STJ505824-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

ABL2 Blocking Peptide for STJ506089 peptide (STJ505824)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	ABL2 Blocking Peptide for STJ506089 is synthetically produced from the 1100-1150 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	ABL2
Gene ID:	27
Uniprot ID:	ABL2_HUMAN
Immunogen Region:	1100-1150
Specificity:	This blocking peptide is recommended for use in combination with ABL2 antibody, STJ506089
Immunogen:	Synthetic peptide corresponding to amino acids within region 1100-1150 on human Tyrosine-protein kinase ABL2/ARG.

Tissue Specificity	Widely expressed.
Post Translational Modifications	Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB. Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.
Function	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement).CTTN (involved in signaling).or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1.
Peptide Name	Tyrosine-Protein Kinase Abl2 Abelson Murine Leukemia Viral Oncogene Homolog 2 Abelson Tyrosine-Protein Kinase 2 Abelson-Related Gene Protein Tyrosine-Protein Kinase Arg
Database Links	Reactome: R-HSA-428890 Reactome: R-HSA-9013149 Reactome: R-HSA-9013423 Reactome: R-HSA-9706369
Cellular Localisation	Cytoplasm Cytoskeleton
Alternative Peptide Names	Tyrosine-Protein Kinase Abl2 protein Abelson Murine Leukemia Viral Oncogene Homolog 2 protein Abelson Tyrosine-Protein Kinase 2 protein Abelson-Related Gene Protein protein Tyrosine-Protein Kinase Arg protein ABL2 protein ABLL protein ARG protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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ABL2 Blocking Peptide for STJ506089 peptide (STJ505824)