Anti-A2M antibody (1155-1474) (STJ118764) STJ118764 上海玉博生物科技有限公司

Anti-A2M antibody (1155-1474) (STJ118764)

简单介绍

Anti-A2M antibody (1155-1474) (STJ118764)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-A2M (1155-1474) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	A2M
Gene ID:	2
Uniprot ID:	A2MG_HUMAN
Immunogen Region:	1155-1474
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human Alpha-2-Macroglobulin (Alpha-2-Macroglobulin (A2M) ) (NP_000005.2).
Immunogen Sequence:	ALAGNQDKRKEVLKSLNEEA VKKDNSVHWERPQKPKAPVG HFYEPQAPSAEVEMTSYVLL AYLTAQPAPTSEDLTSATNI VKWITKQQNAQGGFSSTQDT VVALHALSKYGAATFTRTGK AAQVTIQSSGTFSSKFQVDN NNRLLLQQVSLPELPGEYSM KVTGEGCVYLQTSLKYNILP EKEEFPFALGVQTLPQTCDE PKAHTSFQISLSVSYTGSRS ASNMAIVDVKMVSGFIPLK

Tissue Specificity	Secreted in plasma.
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Protein Name	Alpha-2-Macroglobulin Alpha-2-M C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-140837 Reactome: R-HSA-1474228 Reactome: R-HSA-8963896
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Alpha-2-Macroglobulin antibody Anti-Alpha-2-M antibody Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibody Anti-A2M antibody Anti-CPAMD5 antibody Anti-FWP007 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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