Anti-A2ML1 antibody (400-500) (STJ11102931) STJ11102931 上海玉博生物科技有限公司

Anti-A2ML1 antibody (400-500) (STJ11102931)

简单介绍

Anti-A2ML1 antibody (400-500) (STJ11102931)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-A2ML1 (400-500) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	A2ML1
Gene ID:	144568
Uniprot ID:	A2ML1_HUMAN
Immunogen Region:	400-500
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 400-500 of human A2ML1 (NP_653271.3).
Immunogen Sequence:	PFTLETSGWNGTDVSLEGKF QMEDLVYNPEQVPRYYQNAY LHLRPFYSTTRSFLGIHRLN GPLKCGQPQEVLVDYYIDPA DASPDQEISFSYYLIGKGSL V

Tissue Specificity	In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
Protein Name	Alpha-2-Macroglobulin-Like Protein 1 C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 9
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Alpha-2-Macroglobulin-Like Protein 1 antibody Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 9 antibody Anti-A2ML1 antibody Anti-CPAMD9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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