CD48 protein (STJP000142) STJP000142-50 上海玉博生物科技有限公司

CD48 protein (STJP000142)

简单介绍

CD48 protein (STJP000142)

产品描述

Host:	CHO cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CD48-protein was developed from cho cells. For use in research applications.

Formulation:	PBS pH 7.4
Purification:	Purified by ion-exchange chromatography, hydrophobic interaction chromatography and gel-filtration from serum-free CHO growth media
Concentration:	1 mg/ml
Storage Instruction:	Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles

Gene Symbol:	Cd48
Gene ID:	12506
Uniprot ID:	CD48_MOUSE
Immunogen:	Protein contains mouse CD48 chain (aa 23-217) , propeptide (aa 218-240) is removed

Function	Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells.
Protein Name	Cd48 Antigen Bcm1 Surface Antigen Blast-1 Hm48-1 Mrc Ox-45 Surface Antigen Slam Family Member 2 Slamf2 Signaling Lymphocytic Activation Molecule 2 Sgp-60 Cd Antigen Cd48
Database Links	Reactome: R-MMU-202733
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Secreted
Alternative Protein Names	Cd48 Antigen protein Bcm1 Surface Antigen protein Blast-1 protein Hm48-1 protein Mrc Ox-45 Surface Antigen protein Slam Family Member 2 protein Slamf2 protein Signaling Lymphocytic Activation Molecule 2 protein Sgp-60 protein Cd Antigen Cd48 protein Cd48 protein Bcm-1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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