ALDH1A1 Positive Control for STJ500065 peptide (STJ505318) STJ505318-5 上海玉博生物科技有限公司

ALDH1A1 Positive Control for STJ500065 peptide (STJ505318)

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产品名称：ALDH1A1 Positive Control for STJ500065 peptide (STJ505318)
产品型号：STJ505318-5
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

ALDH1A1 Positive Control for STJ500065 peptide (STJ505318)

产品描述

Applications:	WB
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	ALDH1A1 Positive Control for STJ500065 is synthetically produced from the sequence and is suitable for use in western blot applications.

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range:	WB: 1:2, 500-1:5, 000
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Aldh1a1
Gene ID:	24188
Uniprot ID:	AL1A1_RAT
Specificity:	This is positive control is recommended for use in combination with ALDH1A1 antibody STJ500065.

Tissue Specificity	Strongly expressed in kidney, lung, testis, intestine, stomach, and trachea, but weakly in the liver.
Post Translational Modifications	The N-terminus is blocked most probably by acetylation.
Function	Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins. Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission.
Peptide Name	Aldehyde Dehydrogenase 1a1 3-Deoxyglucosone Dehydrogenase Aldh-E1 Alhdii Aldehyde Dehydrogenase Family 1 Member A1 Aldehyde Dehydrogenase - Cytosolic Retinal Dehydrogenase 1 Raldh 1 Raldh1
Database Links	Reactome: R-RNO-5365859 Reactome: -RNO-70350 Reactome: -RNO-71384
Cellular Localisation	Cytoplasm Cytosol Cell Projection Axon
Alternative Peptide Names	Aldehyde Dehydrogenase 1a1 protein 3-Deoxyglucosone Dehydrogenase protein Aldh-E1 protein Alhdii protein Aldehyde Dehydrogenase Family 1 Member A1 protein Aldehyde Dehydrogenase - Cytosolic protein Retinal Dehydrogenase 1 protein Raldh 1 protein Raldh1 protein Aldh1a1 protein Aldh protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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ALDH1A1 Positive Control for STJ500065 peptide (STJ505318)