Annexin A1 Blocking Peptide for STJ506345 peptide (STJ506347) STJ506347-250 上海玉博生物科技有限公司

Annexin A1 Blocking Peptide for STJ506345 peptide (STJ506347)

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产品名称：Annexin A1 Blocking Peptide for STJ506345 peptide (STJ506347)
产品型号：STJ506347-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Annexin A1 Blocking Peptide for STJ506345 peptide (STJ506347)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Annexin A1 Blocking Peptide for STJ506345 is synthetically produced from the 1-50 aa sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	ANXA1
Gene ID:	301
Uniprot ID:	ANXA1_HUMAN
Immunogen Region:	1-50 aa
Specificity:	This blocking peptide is recommended for use in combination with Annexin A1 antibody, STJ506345

Tissue Specificity	Detected in resting neutrophils. Detected in peripheral blood T-cells. Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors. Detected in placenta (at protein level). Detected in liver.
Post Translational Modifications	Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment. Sumoylated. Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.
Function	Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions. Displays Ca(2+)-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton. Annexin Ac2-26: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
Peptide Name	Annexin A1 Annexin I Annexin-1 Calpactin Ii Calpactin-2 Chromobindin-9 Lipocortin I Phospholipase A2 Inhibitory Protein P35 Cleaved Into - Annexin Ac2-26
Database Links	Reactome: R-HSA-416476 Reactome: R-HSA-418594 Reactome: R-HSA-444473 Reactome: R-HSA-445355 Reactome: R-HSA-6785807
Cellular Localisation	Nucleus Cytoplasm Cell Projection Cilium Cell Membrane Membrane Peripheral Membrane Protein Endosome Membrane Basolateral Cell Membrane Apical Cell Membrane Lateral Cell Membrane Secreted Extracellular Space Extracellular Side Extracellular Exosome Cytoplasmic Vesicle Secretory Vesicle Lumen Phagocytic Cup Early Endosome Cytoplasmic Vesicle Membrane At Least In Part Via Exosomes And Other Secretory Vesicles Detected In Exosomes And Other Extracellular Vesicles Alternatively The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In The Protein Translocation From The Cytoplasm Into Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion Detected In Gelatinase Granules In Resting Neutrophils Secretion Is Increased In Response To Wounding And Inflammation Secretion Is Increased Upon T-Cell Activation Neutrophil Adhesion To Endothelial Cells Stimulates Secretion Via Gelatinase Granules But Foreign Particle Phagocytosis Has No Effect Colocalizes With Actin Fibers At Phagocytic Cups Displays Calcium-Dependent Binding To Phospholipid Membranes
Alternative Peptide Names	Annexin A1 protein Annexin I protein Annexin-1 protein Calpactin Ii protein Calpactin-2 protein Chromobindin-9 protein Lipocortin I protein Phospholipase A2 Inhibitory Protein protein P35 Cleaved Into - Annexin Ac2-26 protein ANXA1 protein ANX1 protein LPC1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Annexin A1 Blocking Peptide for STJ506345 peptide (STJ506347)