Anti-AATF antibody (10-59 aa) (STJ92259) STJ92259 上海玉博生物科技有限公司

Anti-AATF antibody (10-59 aa) (STJ92259)

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产品名称：Anti-AATF antibody (10-59 aa) (STJ92259)
产品型号：STJ92259
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-AATF antibody (10-59 aa) (STJ92259)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Protein AATF (10-59 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	AATF
Gene ID:	26574
Uniprot ID:	AATF_HUMAN
Immunogen Region:	10-59 aa
Specificity:	Che-1 Polyclonal Antibody detects endogenous levels of Che-1 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human the amino acidTF at the amino acid range 10-59

Post Translational Modifications	Hyperphosphorylated during the G1/S phase transition.
Function	Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Protein Name	Protein Aatf Apoptosis-Antagonizing Transcription Factor Rb-Binding Protein Che-1
Database Links	Reactome: R-HSA-193648
Cellular Localisation	Nucleus Nucleolus
Alternative Antibody Names	Anti-Protein Aatf antibody Anti-Apoptosis-Antagonizing Transcription Factor antibody Anti-Rb-Binding Protein Che-1 antibody Anti-AATF antibody Anti-CHE1 antibody Anti-DED antibody Anti-HSPC277 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-AATF antibody (10-59 aa) (STJ92259)