Apelin Blocking Peptide peptide (STJ505516) STJ505516-250 上海玉博生物科技有限公司

Apelin Blocking Peptide peptide (STJ505516)

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产品名称：Apelin Blocking Peptide peptide (STJ505516)
产品型号：STJ505516-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Apelin Blocking Peptide peptide (STJ505516)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Apelin Blocking Peptide is synthetically produced from the 25-77 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	APLN
Gene ID:	8862
Uniprot ID:	APEL_HUMAN
Immunogen Region:	25-77
Immunogen:	Synthetic peptide taken within amino acid region 25-77 on human Apelin protein.

Tissue Specificity	Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.
Post Translational Modifications	Several active peptides may be produced by proteolytic processing of the peptide precursor.
Function	Endogenous ligand for the apelin receptor (APLNR). Drives internalization of the apelin receptor. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR. Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking.the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior. (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives.
Peptide Name	Apelin Apj Endogenous Ligand Cleaved Into - Apelin-36 - Apelin-31 - Apelin-28 - Apelin-13
Database Links	Reactome: R-HSA-375276 Reactome: R-HSA-418594
Cellular Localisation	Secreted Extracellular Space Abundantly Secreted In The Colostrum Lower Level In Milk Decreases Rapidly Within Several Days After Parturition In Milk But Is Still Detectable Even In Commercial Milk
Alternative Peptide Names	Apelin protein Apj Endogenous Ligand Cleaved Into - Apelin-36 - Apelin-31 - Apelin-28 - Apelin-13 protein APLN protein APEL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Apelin Blocking Peptide peptide (STJ505516)