Aquaporin 2 Blocking Peptide peptide (Phospho) (STJ504528) STJ504528-250 上海玉博生物科技有限公司

Aquaporin 2 Blocking Peptide peptide (Phospho) (STJ504528)

简单介绍

Aquaporin 2 Blocking Peptide peptide (Phospho) (STJ504528)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Phospho-Aquaporin 2 Blocking Peptide is synthetically produced from the 200-240 sequence and is suitable for use in western blot applications.

Storage Instruction:

Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Aqp2
Gene ID:	25386
Uniprot ID:	AQP2_RAT
Immunogen Region:	200-240
Immunogen:	Synthetic peptide taken within amino acid region 200-240 on rat Aquaporin 2 protein. Phosphorylated Serine 218 residue.

Tissue Specificity	Detected in kidney, in cortical and the medullary collecting tubules (at protein level). Detected in kidney medulla and cortex.
Post Translational Modifications	Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. N-glycosylated.
Function	Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis.
Peptide Name	Aquaporin-2 Aqp-2 Adh Water Channel Aquaporin-Cd Aqp-Cd Collecting Duct Water Channel Protein Wch-Cd Water Channel Protein For Renal Collecting Duct
Database Links	Reactome: R-RNO-432040 Reactome: -RNO-432047
Cellular Localisation	Apical Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Cell Membrane Cytoplasmic Vesicle Membrane Golgi Apparatus Trans-Golgi Network Membrane Shuttles From Vesicles To The Apical Membrane Vasopressin-Regulated Phosphorylation Is Required For Translocation To The Apical Cell Membrane Plekha8/Fapp2 Is Required To Transport Aqp2 From The Tgn To Sites Where Aqp2 Is Phosphorylated
Alternative Peptide Names	Aquaporin-2 protein Aqp-2 protein Adh Water Channel protein Aquaporin-Cd protein Aqp-Cd protein Collecting Duct Water Channel Protein protein Wch-Cd protein Water Channel Protein For Renal Collecting Duct protein Aqp2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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