Aquaporin 4 Blocking Peptide peptide (STJ503664) STJ503664-250 上海玉博生物科技有限公司

Aquaporin 4 Blocking Peptide peptide (STJ503664)

如果您对该产品感兴趣的话，可以
产品名称：Aquaporin 4 Blocking Peptide peptide (STJ503664)
产品型号：STJ503664-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Aquaporin 4 Blocking Peptide peptide (STJ503664)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Aquaporin 4 Blocking Peptide is synthetically produced from the 300-323 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	AQP4
Gene ID:	361
Uniprot ID:	AQP4_HUMAN
Immunogen Region:	300-323
Immunogen:	Synthetic peptide taken within amino acid region 300-323 on rat Aquaporin 4 protein.

Tissue Specificity	Detected in skeletal muscle. Detected in stomach, along the glandular base region of the fundic gland (at protein level). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary.
Post Translational Modifications	Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40%. Isoform 2: Palmitoylated on its N-terminal region. Isoform 1: Not palmitoylated.
Function	Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability.
Peptide Name	Aquaporin-4 Aqp-4 Mercurial-Insensitive Water Channel Miwc Wch4
Database Links	Reactome: R-HSA-432040 Reactome: R-HSA-432047
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Endosome Membrane Sarcolemma Cell Projection Activation Of The Vasopressin Receptor Avpr1a Triggers Aqp4 Phosphorylation At Ser-180 And Promotes Its Internalization From The Cell Membrane Detected On Brain Astrocyte Processes And Astrocyte Endfeet Close To Capillaries
Alternative Peptide Names	Aquaporin-4 protein Aqp-4 protein Mercurial-Insensitive Water Channel protein Miwc protein Wch4 protein AQP4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

��证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Aquaporin 4 Blocking Peptide peptide (STJ503664)