Anti-ABCB11 antibody (1050-1150) (STJ116895) STJ116895 上海玉博生物科技有限公司

Anti-ABCB11 antibody (1050-1150) (STJ116895)

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产品名称：Anti-ABCB11 antibody (1050-1150) (STJ116895)
产品型号：STJ116895
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ABCB11 antibody (1050-1150) (STJ116895)

产品描述

Host:	Rabbit
Applications:	IF
Reactivity:	Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ABCB11 (1050-1150) is suitable for use in Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCB11
Gene ID:	8647
Uniprot ID:	ABCBB_HUMAN
Immunogen Region:	1050-1150
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human ABCB11 (NP_003733.2).
Immunogen Sequence:	RFFQLLDRQPPISVYNTAGE KWDNFQGKIDFVDCKFTYPS RPDSQVLNGLSVSISPGQTL AFVGSSGCGKSTSIQLLERF YDPDQGKVMIDGHDSKKVNV Q

Tissue Specificity	Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Post Translational Modifications	N-glycosylated. Ubiquitinated.short-chain ubiquitination regulates cell-Surface expression of ABCB11.
Function	Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
Protein Name	Bile Salt Export Pump Atp-Binding Cassette Sub-Family B Member 11
Database Links	Reactome: R-HSA-159418 Reactome: R-HSA-193368 Reactome: R-HSA-5678520
Cellular Localisation	Apical Cell Membrane Multi-Pass Membrane Protein Recycling Endosome Membrane Endosome Cell Membrane Internalized At The Canalicular Membrane Through Interaction With The Adapter Protein Complex 2 (Ap-2) At Steady State Localizes In The Canalicular Membrane But Is Also Present In Recycling Endosomes Abcb11 Constantly And Rapidly Exchanges Between The Two Sites Through Tubulo-Vesicles Carriers That Move Along Microtubules Microtubule-Dependent Trafficking Of Abcb11 Is Enhanced By Taurocholate And Camp And Regulated By Stk11 Through A Pka-Mediated Pathway Trafficking Of Newly Synthesized Abcb11 Through Endosomal Compartment To The Bile Canalicular Membrane Is Accelerated By Camp But Not By Taurocholate Cell Membrane Expression Is Up-Regulated By Short- And Medium-Chain Fatty Acids
Alternative Antibody Names	Anti-Bile Salt Export Pump antibody Anti-Atp-Binding Cassette Sub-Family B Member 11 antibody Anti-ABCB11 antibody Anti-BSEP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ABCB11 antibody (1050-1150) (STJ116895)