Anti-ABCB11 antibody (STJ190611) STJ190611 上海玉博生物科技有限公司

Anti-ABCB11 antibody (STJ190611)

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产品名称：Anti-ABCB11 antibody (STJ190611)
产品型号：STJ190611
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ABCB11 antibody (STJ190611)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Bile salt export pump is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCB11
Gene ID:	8647
Uniprot ID:	ABCBB_HUMAN
Specificity:	ABCBB Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from part of the human protein

Post Translational Modifications	N-glycosylated. Ubiquitinated.short-chain ubiquitination regulates cell-Surface expression of ABCB11.
Function	Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
Protein Name	Bile Salt Export Pump Atp-Binding Cassette Sub-Family B Member 11
Database Links	Reactome: R-HSA-159418 Reactome: R-HSA-193368 Reactome: R-HSA-5678520
Cellular Localisation	Apical Cell Membrane Multi-Pass Membrane Protein Recycling Endosome Membrane Endosome Cell Membrane Internalized At The Canalicular Membrane Through Interaction With The Adapter Protein Complex 2 (Ap-2) At Steady State Localizes In The Canalicular Membrane But Is Also Present In Recycling Endosomes Abcb11 Constantly And Rapidly Exchanges Between The Two Sites Through Tubulo-Vesicles Carriers That Move Along Microtubules Microtubule-Dependent Trafficking Of Abcb11 Is Enhanced By Taurocholate And Camp And Regulated By Stk11 Through A Pka-Mediated Pathway Trafficking Of Newly Synthesized Abcb11 Through Endosomal Compartment To The Bile Canalicular Membrane Is Accelerated By Camp But Not By Taurocholate Cell Membrane Expression Is Up-Regulated By Short- And Medium-Chain Fatty Acids
Alternative Antibody Names	Anti-Bile Salt Export Pump antibody Anti-Atp-Binding Cassette Sub-Family B Member 11 antibody Anti-ABCB11 antibody Anti-BSEP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ABCB11 antibody (STJ190611)