Anti-ABCB4 antibody (20-100 aa) (STJ190988) STJ190988 上海玉博生物科技有限公司

Anti-ABCB4 antibody (20-100 aa) (STJ190988)

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产品名称：Anti-ABCB4 antibody (20-100 aa) (STJ190988)
产品型号：STJ190988
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ABCB4 antibody (20-100 aa) (STJ190988)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Phosphatidylcholine translocator ABCB4 (20-100 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCB4
Gene ID:	5244
Uniprot ID:	MDR3_HUMAN
Immunogen Region:	20-100 aa
Specificity:	MDR3 Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from the human protein at the amino acid range 20-100

Function	Isoform 1: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance.
Protein Name	Phosphatidylcholine Translocator Abcb4 Atp-Binding Cassette Sub-Family B Member 4 Multidrug Resistance Protein 3 P-Glycoprotein 3
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-382556 Reactome: R-HSA-5678771
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Membrane Raft Cytoplasm Cytoplasmic Vesicle Clathrin-Coated Vesicle Localized At The Apical Canalicular Membrane Of The Epithelial Cells Lining The Lumen Of The Bile Canaliculi And Biliary Ductules Transported From The Golgi To The Apical Bile Canalicular Membrane In A Rack1-Dependent Manner Redistributed Into Pseudocanaliculi Formed Between Cells In A Bezafibrate- Or Ppara-Dependent Manner Localized Preferentially In Lipid Nonraft Domains Of Canalicular Plasma Membranes
Alternative Antibody Names	Anti-Phosphatidylcholine Translocator Abcb4 antibody Anti-Atp-Binding Cassette Sub-Family B Member 4 antibody Anti-Multidrug Resistance Protein 3 antibody Anti-P-Glycoprotein 3 antibody Anti-ABCB4 antibody Anti-MDR3 antibody Anti-PGY3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ABCB4 antibody (20-100 aa) (STJ190988)