Anti-ABCB5 antibody (40-120) (STJA0010104) STJA0010104 上海玉博生物科技有限公司

Anti-ABCB5 antibody (40-120) (STJA0010104)

简单介绍

Anti-ABCB5 antibody (40-120) (STJA0010104)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ATP-binding cassette sub-family B member 5 (40-120) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCB5
Gene ID:	340273
Uniprot ID:	ABCB5_HUMAN
Immunogen Region:	40-120
Specificity:	This antibody detects endogenous levels of Human ABCB5
Immunogen:	Synthesized peptide derived from human ABCB5 AA range: 40-120

Tissue Specificity	Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
Function	Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
Protein Name	Atp-Binding Cassette Sub-Family B Member 5 Abcb5 P-Gp P-Glycoprotein Abcb5
Database Links	Reactome: R-HSA-382556
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family B Member 5 antibody Anti-Abcb5 P-Gp antibody Anti-P-Glycoprotein Abcb5 antibody Anti-ABCB5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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