Anti-ABCB6 antibody (STJA0007484) STJA0007484 上海玉博生物科技有限公司

Anti-ABCB6 antibody (STJA0007484)

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产品名称：Anti-ABCB6 antibody (STJA0007484)
产品型号：STJA0007484
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ABCB6 antibody (STJA0007484)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ATP-binding cassette sub-family B member 6 is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCB6
Gene ID:	10058
Uniprot ID:	ABCB6_HUMAN
Specificity:	This antibody detects endogenous levels of ABCB6 at Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human ABCB6

Post Translational Modifications	N-glycosylated.
Function	ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis.
Protein Name	Atp-Binding Cassette Sub-Family B Member 6 Abc-Type Heme Transporter Abcb6 Mitochondrial Abc Transporter 3 Mt-Abc Transporter 3 P-Glycoprotein-Related Protein Ubiquitously-Expressed Mammalian Abc Half Transporter
Database Links	Reactome: R-HSA-1369007 Reactome: R-HSA-5683371
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Mitochondrion Outer Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Endosome Membrane Lysosome Membrane Late Endosome Membrane Early Endosome Membrane Secreted Extracellular Exosome Mitochondrion Endosome Multivesicular Body Membrane Melanosome Membrane Present In The Membrane Of Mature Erythrocytes And In Exosomes Released From Reticulocytes During The Final Steps Of Erythroid Maturation Traffics From Endoplasmic Reticulum To Golgi During Its Glycans's Maturation Therefrom Is First Targeted To The Plasma Membrane And Is Rapidly Internalized Through Endocytosis To Be Distributed To The Limiting Membrane Of Multivesicular Bodies And Lysosomes Localized On The Limiting Membrane Of Early Melanosomes Of Pigment Cells Targeted To The Endolysosomal Compartment
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family B Member 6 antibody Anti-Abc-Type Heme Transporter Abcb6 antibody Anti-Mitochondrial Abc Transporter 3 antibody Anti-Mt-Abc Transporter 3 antibody Anti-P-Glycoprotein-Related Protein antibody Anti-Ubiquitously-Expressed Mammalian Abc Half Transporter antibody Anti-ABCB6 antibody Anti-MTABC3 antibody Anti-PRP antibody Anti-UMAT antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ABCB6 antibody (STJA0007484)