Anti-ABCC11 antibody (1-170) (STJ28597) STJ28597 上海玉博生物科技有限公司

Anti-ABCC11 antibody (1-170) (STJ28597)

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产品名称：Anti-ABCC11 antibody (1-170) (STJ28597)
产品型号：STJ28597
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ABCC11 antibody (1-170) (STJ28597)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ABCC11 (1-170) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCC11
Gene ID:	85320
Uniprot ID:	MRP8_HUMAN
Immunogen Region:	1-170
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ABCC11 (NP_660187.1).
Immunogen Sequence:	MTRKRTYWVPNSSGGLVNRG IDIGDDMVSGLIYKTYTLQD GPWSQQERNPEAPGRAAVPP WGKYDAALRTMIPFRPKPRF PAPQPLDNAGLFSYLTVSWL TPLMIQSLRSRLDENTIPPL SVHDASDKNVQRLHRLWEEE VSRRGIEKASVLLVMLRFQR TRLIFDALLG

Tissue Specificity	Expressed in ceruminous apocrine gland (at protein level). Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta. Localizes to axons of the CNS and peripheral nervous system (at protein level).
Function	ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Enhances also the cellular extrusion of cAMP and cGMP. Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate. Probably functions to secrete earwax. Required for the secretion of components contributing to axillary odor formation.
Protein Name	Atp-Binding Cassette Sub-Family C Member 11 Multidrug Resistance-Associated Protein 8
Database Links	Reactome: R-HSA-382556
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Vacuole Membrane Cytoplasmic Vesicle Membrane Apical Cell Membrane
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family C Member 11 antibody Anti-Multidrug Resistance-Associated Protein 8 antibody Anti-ABCC11 antibody Anti-MRP8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ABCC11 antibody (1-170) (STJ28597)