Anti-ABCC3 antibody (971-1020) (STJ94206) STJ94206 上海玉博生物科技有限公司

Anti-ABCC3 antibody (971-1020) (STJ94206)

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产品名称：Anti-ABCC3 antibody (971-1020) (STJ94206)
产品型号：STJ94206
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ABCC3 antibody (971-1020) (STJ94206)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ATP-binding cassette sub-family C member 3 (971-1020) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 IHC-p 1:50-300
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ABCC3
Gene ID:	8714
Uniprot ID:	MRP3_HUMAN
Immunogen Region:	971-1020
Specificity:	MRP3 Polyclonal Antibody detects endogenous levels of MRP3 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from human ABCC3. AA range:971-1020

Tissue Specificity	Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules.
Function	ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells.
Protein Name	Atp-Binding Cassette Sub-Family C Member 3 Canalicular Multispecific Organic Anion Transporter 2 Multi-Specific Organic Anion Transporter D Moat-D Multidrug Resistance-Associated Protein 3
Database Links	Reactome: R-HSA-159418 Reactome: R-HSA-382556 Reactome: R-HSA-9749641 Reactome: R-HSA-9753281
Cellular Localisation	Basolateral Cell Membrane Multi-Pass Membrane Protein Basal Cell Membrane Localized To The Basolateral Membrane Of Enterocytes Localized To The Basal Membrane Of Sertoli Cells
Alternative Antibody Names	Anti-Atp-Binding Cassette Sub-Family C Member 3 antibody Anti-Canalicular Multispecific Organic Anion Transporter 2 antibody Anti-Multi-Specific Organic Anion Transporter D antibody Anti-Moat-D antibody Anti-Multidrug Resistance-Associated Protein 3 antibody Anti-ABCC3 antibody Anti-CMOAT2 antibody Anti-MLP2 antibody Anti-MRP3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ABCC3 antibody (971-1020) (STJ94206)