Human CD155/PVR protein (Recombinant) (C-hFc) {Biotin} (STJP001728) STJP001728 上海玉博生物科技有限公司

Human CD155/PVR protein (Recombinant) (C-hFc) {Biotin} (STJP001728)

如果您对该产品感兴趣的话，可以
产品名称：Human CD155/PVR protein (Recombinant) (C-hFc) {Biotin} (STJP001728)
产品型号：STJP001728
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human CD155/PVR protein (Recombinant) (C-hFc) {Biotin} (STJP001728)

产品描述

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD155/PVR-C-hFc protein was developed from hek293 and has a target region of C-hFc. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range:	Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction:	The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).

Gene Symbol:	PVR
Gene ID:	5817
Uniprot ID:	PVR_HUMAN
Immunogen Region:	Trp21-Asn343
Immunogen:	DNA sequence encoding Human CD155/PVR (Primary Amine Labeling) including a C-hFc tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.

Function	Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.
Protein Name	Poliovirus Receptor Nectin-Like Protein 5 Necl-5 Cd Antigen Cd155
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-420597
Cellular Localisation	Isoform Alpha: Cell Membrane Single-Pass Type I Membrane Protein Isoform Delta: Cell Membrane Isoform Beta: Secreted Isoform Gamma: Secreted
Alternative Protein Names	Poliovirus Receptor protein Nectin-Like Protein 5 protein Necl-5 protein Cd Antigen Cd155 protein PVR protein PVS protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Human CD155/PVR protein (Recombinant) (C-hFc) {Biotin} (STJP001728)