Human CD161 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001541) STJP001541 上海玉博生物科技有限公司

Human CD161 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001541)

简单介绍

Human CD161 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001541)

产品描述

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD161-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range:	Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction:	The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).

Gene Symbol:	KLRB1
Gene ID:	3820
Uniprot ID:	KLRB1_HUMAN
Immunogen Region:	Gln67-Ser225
Immunogen:	DNA sequence encoding Human CD161 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.

Post Translational Modifications	N-glycosylated. Contains sialic acid residues.
Function	Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein Name	Killer Cell Lectin-Like Receptor Subfamily B Member 1 C-Type Lectin Domain Family 5 Member B Hnkr-P1a Nkr-P1a Natural Killer Cell Surface Protein P1a Cd Antigen Cd161
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Membrane Single-Pass Type Ii Membrane Protein
Alternative Protein Names	Killer Cell Lectin-Like Receptor Subfamily B Member 1 protein C-Type Lectin Domain Family 5 Member B protein Hnkr-P1a protein Nkr-P1a protein Natural Killer Cell Surface Protein P1a protein Cd Antigen Cd161 protein KLRB1 protein CLEC5B protein NKRP1A protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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