Human CD163 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001549) STJP001549 上海玉博生物科技有限公司

Human CD163 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001549)

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产品名称：Human CD163 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001549)
产品型号：STJP001549
产品展商：ST john's laboratory
产品文档：无相关文档

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Human CD163 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001549)

产品描述

Host:	HEK293
Note:	STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD163-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.

Conjugation:	Biotin
Formulation:	Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range:	Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction:	The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:	Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).

Gene Symbol:	CD163
Gene ID:	9332
Uniprot ID:	C163A_HUMAN
Immunogen Region:	Ser42-Ser1045
Immunogen:	DNA sequence encoding Human CD163 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.

Post Translational Modifications	A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.
Function	Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Protein Name	Scavenger Receptor Cysteine-Rich Type 1 Protein M130 Hemoglobin Scavenger Receptor Cd Antigen Cd163 Cleaved Into - Soluble Cd163 Scd163
Database Links	Reactome: R-HSA-2168880 Reactome: R-HSA-9662834
Cellular Localisation	Soluble Cd163: Secreted Cell Membrane Single-Pass Type I Membrane Protein Isoform 1 And Isoform 2 Show A Lower Surface Expression When Expressed In Cells
Alternative Protein Names	Scavenger Receptor Cysteine-Rich Type 1 Protein M130 protein Hemoglobin Scavenger Receptor protein Cd Antigen Cd163 Cleaved Into - Soluble Cd163 protein Scd163 protein CD163 protein M130 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human CD163 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001549)