Human CD24 protein (Active Recombinant) (C-hFc) (STJP001243) STJP001243 上海玉博生物科技有限公司

Human CD24 protein (Active Recombinant) (C-hFc) (STJP001243)

简单介绍

Human CD24 protein (Active Recombinant) (C-hFc) (STJP001243)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Active Recombinant-Human CD24-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human CD24 at 2 Mu g/mL (100 Mu L/well) can bind Human Siglec10 with a linear range of 1-764 ng/mL.2. Measured by its binding ability in a functional ELISA. Immobilized PE Mouse Anti-

Gene Symbol:	CD24
Gene ID:	100133941
Uniprot ID:	CD24_HUMAN
Immunogen Region:	Met1-Gly59
Immunogen:	Recombinant Human CD24 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gly59) of human CD24 (Accession #NP_037362) fused with a Fc tag at the C-terminus.

Tissue Specificity	B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
Post Translational Modifications	Extensively O-glycosylated.
Function	May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
Protein Name	Signal Transducer Cd24 Small Cell Lung Carcinoma Cluster 4 Antigen Cd Antigen Cd24
Database Links	Reactome: R-HSA-373760
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor
Alternative Protein Names	Signal Transducer Cd24 protein Small Cell Lung Carcinoma Cluster 4 Antigen protein Cd Antigen Cd24 protein CD24 protein CD24A protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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