Human CD28 protein (Recombinant) (C-His) (STJP000911) STJP000911 上海玉博生物科技有限公司

Human CD28 protein (Recombinant) (C-His) (STJP000911)

简单介绍

Human CD28 protein (Recombinant) (C-His) (STJP000911)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD28-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human CD28 Protein at 1 Mu g/mL (100 Mu L/well) can bind CD28 Rabbit mAb with a linear range of 0.06-1.04 ng/mL.

Gene Symbol:	CD28
Gene ID:	940
Uniprot ID:	CD28_HUMAN
Immunogen Region:	Asn19-Pro152
Immunogen:	Recombinant Human CD28 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asn19-Pro152) of human CD28/TP44 (Accession #NP_006130.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Expressed in T-cells and plasma cells, but not in less mature B-cells.
Post Translational Modifications	CD40LG induces tyrosine phosphorylation of isoform 3.
Function	Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
Protein Name	T-Cell-Specific Surface Glycoprotein Cd28 Tp44 Cd Antigen Cd28
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-164939 Reactome: R-HSA-2219530 Reactome: R-HSA-389356 Reactome: R-HSA-389357 Reactome: R-HSA-389359 Reactome: R-HSA-6811558
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein Isoform 3: Cell Surface
Alternative Protein Names	T-Cell-Specific Surface Glycoprotein Cd28 protein Tp44 protein Cd Antigen Cd28 protein CD28 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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