Human CD3 delta/CD3D protein (Recombinant) (C-His) (STJP002013) STJP002013-100 上海玉博生物科技有限公司

Human CD3 delta/CD3D protein (Recombinant) (C-His) (STJP002013)

如果您对该产品感兴趣的话，可以
产品名称：Human CD3 delta/CD3D protein (Recombinant) (C-His) (STJP002013)
产品型号：STJP002013-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human CD3 delta/CD3D protein (Recombinant) (C-His) (STJP002013)

产品描述

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CD3 delta/CD3D-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:	Lyophilized from a 0.2 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CD3D
Gene ID:	915
Uniprot ID:	CD3D_HUMAN
Immunogen Region:	Phe22-Ala105
Immunogen:	Recombinant Human CD20 Protein is produced by mammalian expression system. The target protein is expressed with sequence (Phe22-Ala105) of human CD3 Delta (Accession #P04234) fused with a 6xHis tag at the C-terminus.

Post Translational Modifications	Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Function	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.
Protein Name	T-Cell Surface Glycoprotein Cd3 Delta Chain T-Cell Receptor T3 Delta Chain Cd Antigen Cd3d
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-202424 Reactome: R-HSA-202427 Reactome: R-HSA-202430 Reactome: R-HSA-202433 Reactome: R-HSA-389948 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	T-Cell Surface Glycoprotein Cd3 Delta Chain protein T-Cell Receptor T3 Delta Chain protein Cd Antigen Cd3d protein CD3D protein T3D protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Human CD3 delta/CD3D protein (Recombinant) (C-His) (STJP002013)