CD163 Blocking Peptide for STJ500423 peptide (STJ503789) STJ503789-250 上海玉博生物科技有限公司

CD163 Blocking Peptide for STJ500423 peptide (STJ503789)

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产品名称：CD163 Blocking Peptide for STJ500423 peptide (STJ503789)
产品型号：STJ503789-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

CD163 Blocking Peptide for STJ500423 peptide (STJ503789)

产品描述

Applications:	ELISA/CM/ICC/IF/IHC/IP/WB
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CD163 Blocking Peptide for STJ500423 is synthetically produced from the 600-650 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Immunogen Region:	600-650
Specificity:	This blocking peptide is recommended for use in combination with CD163 antibody, STJ500423
Immunogen:	Synthetic peptide taken within amino acid region 600-650 on human CD163 protein.

Background

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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CD163 Blocking Peptide for STJ500423 peptide (STJ503789)