CD19 Blocking Peptide peptide (STJ503791) STJ503791-250 上海玉博生物科技有限公司

CD19 Blocking Peptide peptide (STJ503791)

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产品名称：CD19 Blocking Peptide peptide (STJ503791)
产品型号：STJ503791-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

CD19 Blocking Peptide peptide (STJ503791)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CD19 Blocking Peptide is synthetically produced from the 228-242 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CD19
Gene ID:	930
Uniprot ID:	CD19_HUMAN
Immunogen Region:	228-242
Immunogen:	Synthetic peptide within Human CD19 amino acid region 228-242. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. Sequence: LELKDDRPARDMWVM

Tissue Specificity	Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level).
Post Translational Modifications	Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels.
Function	Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
Peptide Name	B-Lymphocyte Antigen Cd19 B-Lymphocyte Surface Antigen B4 Differentiation Antigen Cd19 T-Cell Surface Antigen Leu-12 Cd Antigen Cd19
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-198933 Reactome: R-HSA-2219530 Reactome: R-HSA-6811558 Reactome: R-HSA-977606 Reactome: R-HSA-983695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft
Alternative Peptide Names	B-Lymphocyte Antigen Cd19 protein B-Lymphocyte Surface Antigen B4 protein Differentiation Antigen Cd19 protein T-Cell Surface Antigen Leu-12 protein Cd Antigen Cd19 protein CD19 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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CD19 Blocking Peptide peptide (STJ503791)