CD8 alpha Blocking Peptide for STJ505971 peptide (STJ505746) STJ505746-250 上海玉博生物科技有限公司

CD8 alpha Blocking Peptide for STJ505971 peptide (STJ505746)

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产品名称：CD8 alpha Blocking Peptide for STJ505971 peptide (STJ505746)
产品型号：STJ505746-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

CD8 alpha Blocking Peptide for STJ505971 peptide (STJ505746)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CD8 alpha Blocking Peptide for STJ505971 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CD8A
Gene ID:	925
Uniprot ID:	CD8A_HUMAN
Immunogen Region:	1-50
Specificity:	This blocking peptide is recommended for use in combination with CD8 alpha antibody, STJ505971
Immunogen:	Synthetic peptide taken within amino acid region 1-50 on human T-cell surface glycoprotein CD8 Alpha chain.

Post Translational Modifications	Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts. O-glycosylated. Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
Function	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Peptide Name	T-Cell Surface Glycoprotein Cd8 Alpha Chain T-Lymphocyte Differentiation Antigen T8/Leu-2 Cd Antigen Cd8a
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Cd8a Localizes To Lipid Rafts Only When Associated With Its Partner Cd8b Isoform 2: Secreted
Alternative Peptide Names	T-Cell Surface Glycoprotein Cd8 Alpha Chain protein T-Lymphocyte Differentiation Antigen T8/Leu-2 protein Cd Antigen Cd8a protein CD8A protein MAL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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CD8 alpha Blocking Peptide for STJ505971 peptide (STJ505746)