CD86 Blocking Peptide for STJ500487 peptide (STJ503837) STJ503837-250 上海玉博生物科技有限公司

CD86 Blocking Peptide for STJ500487 peptide (STJ503837)

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产品名称：CD86 Blocking Peptide for STJ500487 peptide (STJ503837)
产品型号：STJ503837-250
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

CD86 Blocking Peptide for STJ500487 peptide (STJ503837)

产品描述

Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	CD86 Blocking Peptide for STJ500487 is synthetically produced from the 250-329 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CD86
Gene ID:	942
Uniprot ID:	CD86_HUMAN
Immunogen Region:	250-329
Specificity:	This blocking peptide is recommended for use in combination with CD86 antibody, STJ500487
Immunogen:	Synthetic peptide taken within amino acid region 250-329 on human CD86 protein.

Tissue Specificity	Expressed by activated B-lymphocytes and monocytes.
Post Translational Modifications	Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Function	Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Peptide Name	T-Lymphocyte Activation Antigen Cd86 Activation B7-2 Antigen B70 Bu63 Ctla-4 Counter-Receptor B7.2 Fun-1 Cd Antigen Cd86
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-2219530 Reactome: R-HSA-389356 Reactome: R-HSA-389357 Reactome: R-HSA-389359 Reactome: R-HSA-389513 Reactome: R-HSA-6783783 Reactome: R-HSA-6811558
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Peptide Names	T-Lymphocyte Activation Antigen Cd86 protein Activation B7-2 Antigen protein B70 protein Bu63 protein Ctla-4 Counter-Receptor B7.2 protein Fun-1 protein Cd Antigen Cd86 protein CD86 protein CD28LG2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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CD86 Blocking Peptide for STJ500487 peptide (STJ503837)